replication deficient aav2 virus Search Results


replication deficient aav2 virus  (Vector Biolabs)
95
Vector Biolabs replication deficient aav2 virus
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Replication Deficient Aav2 Virus, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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purified cmv-egfp aav-2 particles  (Genecopoeia)
93
Genecopoeia purified cmv-egfp aav-2 particles
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
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aav 2/10 rep/cap plasmid  (Agilent technologies)
90
Agilent technologies aav 2/10 rep/cap plasmid
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2/10 Rep/Cap Plasmid, supplied by Agilent technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav 2 9  (Vector Biolabs)
95
Vector Biolabs aav 2 9
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2 9, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav 2 particles  (Vector Biolabs)
95
Vector Biolabs aav 2 particles
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2 Particles, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav-2_darpin  (Affibody)
90
Affibody aav-2_darpin
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2 Darpin, supplied by Affibody, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav-2 for immunological assays  (Remedi Consortium)
90
Remedi Consortium aav-2 for immunological assays
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
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aav-2  (Adverum Inc)
90
Adverum Inc aav-2
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2, supplied by Adverum Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav-2-aadc  (Genzyme)
90
Genzyme aav-2-aadc
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2 Aadc, supplied by Genzyme, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav 2/8  (Partners HealthCare System Inc)
90
Partners HealthCare System Inc aav 2/8
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2/8, supplied by Partners HealthCare System Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav 2/1 -hsyn-flex-jrgeco1a  (Addgene inc)
90
Addgene inc aav 2/1 -hsyn-flex-jrgeco1a
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
Aav 2/1 Hsyn Flex Jrgeco1a, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aav-2  (Avigen Inc)
90
Avigen Inc aav-2
Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
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Image Search Results


Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.

Journal: Scientific Reports

Article Title: Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

doi: 10.1038/s41598-018-23894-2

Figure Lengend Snippet: Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.

Article Snippet: For RGC-selective deletion of the gene, Panx1 fl/fl mice received intraocular injection of a replication-deficient AAV2 virus carrying a CRE expression cassette (AAV2-Cre/GFP, Vector Biolabs, Philadelphia, PA), which transduced approximately 85–90% of the RGCs with only minimal transduction of some Müller cells (Schmitt et al . ).

Techniques: Infection, Construct, Injection, MANN-WHITNEY